On a game to game basis, you might make a 1 rune choice difference, but overall there are still guaranteed obvious choices. The only change you make is very minimally based on the enemy champion choices.I was min maxing Jhin runes for months and found that very rarely I would change from Manaflow Band to Nullifying Orb and run D Ring instead of D blade, but even that just very rarely affected my game in any form, and more often than not I would preferred Manaflow even in games where Nullifying Orb should be good.You bring up super niche arguments of very small instance cases. Like Fiora will never not run Conqueror, unless she against something that stomps her and then she might consider Grasp.
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